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Immune Thrombocytopenias

Worldwide recognition. State-of-the-art testing.

Versiti Diagnostic Labs thrives with the scientific and medical expertise of Dr. Brian Curtis and Dr. Ruchika Sharma.

With worldwide recognition, and these expert resources—available only at BloodCenter of Wisconsin, part of Versiti—referring health care providers gain diagnostic confidence and actionable results for their patients.

Health care professional administering a vaccine dose.

Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT)

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Rare cases of thrombosis with thrombocytopenia have been reported following COVID-19 vaccination. Versiti offers several testing options for patients that develop symptoms of suspected VITT.

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3d illustration of an activated platelets

P-Selectin Expression Assay (PEA)

Order Code: 5502

The next evolution in Heparin-Induced Thrombocytopenia (HIT) diagnostics is here. Versiti’s PEA is able to detect more patient with HIT antibodies, with an industry-leading 24-hour turnaround time.

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Immune Thrombocytopenias

  • Overview

    Thrombocytopenias due to increased destruction are often caused by antibodies that bind to platelets and result in increased clearance from circulation. Antibodies can form against platelet-specific alloantigens and neoantigens that are created when a drug binds to a platelet membrane protein. Platelet antibodies are important in clinical conditions including:

    • Neonatal alloimmune thrombocytopenia 
    • Drug-induced thrombocytopenia (including Heparin-Induced Thrombocytopenia or HIT) 
    • Idiopathic thrombotic thrombocytopenia purpura (ITP) 
    • Platelet alloantigen sensitization due to transfusion


    With our highly developed testing methods, advanced facilities,and some of the world’s leading experts, Versiti helps physicians diagnose and determine the best course of treatment for patients with these challenging conditions.

  • Approach

    Technically demanding assays for actionable results.

    The Platelet & Neutrophil Immunology Laboratory (PNIL) at BloodCenter of Wisconsin, part of Versiti, is internationally known for its testing in Immune Thrombocytopenias. BloodCenter is one of a handful of labs in the U.S. that performs the technically demanding Serotonin Release Assay to detect antibodies that cause Heparin-Induced Thrombocytopenia (HIT). The laboratory has also developed highly sensitive assays for the detection and identification of antibodies directed to platelet alloantigens.


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