Myeloproliferative Neoplasms

Diagnosing Myeloproliferative Neoplasm (MPN) disorders presents unique challenges. Versiti can simplify and streamline the diagnostic process for you. Our experienced Diagnostic Laboratories team, and our desire to provide you with industry-leading service, allow us to provide you with much more than a test result.

Myeloproliferative Neoplasms

Overview
Myeloproliferative neoplasms (MPNs) are a group of diseases that affect blood cell formation. They are characterized by the proliferation of one or more myeloid cell lines in bone marrow, and increased numbers of mature and immature cells in the peripheral blood. Classic myeloproliferative disorders include:
- Polycythemia vera (PV)
- Essential thrombocythemia (ET)
- Primary myelofibrosis (PMF)
  Differential diagnosis of these disorders is critical to selecting the appropriate therapy for your patient. In addition to utilizing our state-of-the-art testing facilities, Versiti’s experienced team will work closely with you in test utilization decisions, test result interpretation and treatment selection.
Approach

An integrated, innovative suite of tests.
Versiti’s MPN testing algorithm uses an integrated suite of molecular tests that detect three markers directly associated with MPNs.

Molecular diagnostic algorithm for MPNs

Diagnostic Labs Tests

Two reflex test options are available for Myeloproliferative Neoplasm testing. When ordered as a reflex panel, if PV is suspected, Patients in whom JAK2 V617F mutations are not detected will automatically reflex to the JAK2 Exon 12 testing. If ETor PMF are suspected, patients in whom JAK2 V617F mutations are not detected will automatically undergo CALR testing. If CALR mutations are not detected, they will automatically reflex to MPL Exon 10 mutation analysis.