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Human Platelet Antigen (HPA) Database

The database provides a centralized repository for discovered and known human platelet antigens.

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Human Platelet Antigen (HPA) Database


This database serves as the principal site for cataloging the current list of human platelet allo-antigens (HPA). To submit data and obtain confirmation and numbering of newly discovered HPA by the International Platelet Immunology Nomenclature Committee of the International Society of Blood Transfusion (ISBT), please use the official forms and instructions on this page.

Alloantibodies against HPA are the cause of several immune platelet disorders, including fetal and neonatal alloimmune thrombocytopenia (FNAIT) and platelet transfusion refractoriness (PTR). Detection and identification of HPA alloantibodies is critical in making a proper diagnosis and for ensuring appropriate patient care.

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HPA Database


Use the database below to search for any of the current 35 recognized human platelet antigens. Search by number, 1-35 to jump to a specific antigen.

System Antigen Original Names Glycoprotein CD Reference
HPA-1

HPA-1a
HPA-1b

Zwa, PlA1 Zwb,PIA2

GPIIIa / †p.L33P

CD61

van Loghem et al, Vox Sang 4:161-9 (1959)
Shulman et al, J Clin Invest 40:1597-1620 (1961)

van der Weerdt et al, Vox Sang 8:513-30 (1963)

HPA-2

HPA-2a
HPA-2b

Kob Koa, Siba

GPIbα / p.T145M

CD42b

van der Weerdt et al, Proc. 8th Congress European Society of Haematology,
Vienna 1961. Karger, Basel .P379
van der Weerdt Thesis 1965, University of Amsterdam

HPA-3

HPA-3a
HPA-3b

Baka, Leka Bakb

GPIIIa

CD61

von dem Borne et al, Vox Sang 39:113-20 (1980)
Kickler et al, Blood 71:894-8 (1988)

HPA-4

HPA-4a
HPA-4b

Yukb, Pena
Yuka, Penb

GPIIIa / p.R143Q

CD61

Friedman et al, Blood 65:1412-5 (1985)
Shibata et al, Vox Sang 50:177-80 (1986)

Shibata et al, Vox Sang 51:334-6 (1986)

HPA-5

HPA-5a
HPA-5b

Brb, Zavb
Bra, Zava, Hca

GPIa / p.E505K

CD49b

Kiefel et al, Vox Sang 54:101-6 (1998)
Kiefel et al, Blood 73:2219-23 (1989)

Santoso et al, Br J Haematol 72:191-8 (1989)

HPA-6b

Caa, Tua

GPIIIa / R489Q

CD61

Kekomaki et al, Br J Haematol 83:306-10 (1993)
McFarland et al, Blood 81:3318-23 (1993)

HPA-7b

Moa

GPIIIa / P407A

CD61

Kuijpers et al, Blood 81:70-6 (1993)

HPA-8b

Sra

GPIIIa / R636C

CD61

Kroll et al, Blood 76:2296-302 (1990)

HPA-9b

Maxa

GPIIb / V837M

CD41

Noris et al, Blood 86:1019-26 (1995)

HPA-10b

Laa

GPIIIa / R62Q

CD61

Peyruchaud et al, Blood 89:2422-8 (1997)

HPA-11b

Groa

GPIIIa / R633H

CD61

Simsek et al, Vox Sang 67:302-6 (1994)

HPA-12b

Iya

GPIbβ / G15E

CD42c

Kiefel, et al, Vox Sang 69:250-4 (1995)

HPA-13b

Sita

GPIIIa / K611del

CD49b

Santoso et al, Blood 94:4103-11 (1999)

HPA-14b

Oea

GPIIIa / K611del

CD61

Santoso et al, Blood 99:1205-14 (2002)

HPA-15

HPA-15a
HPA-15b

Govb
Gova

CD109 / S682Y

CD109

Kelton et al, Blood 75:2172-6 (1990)
Smith et al, Blood 86:2807-14 (1995)

HPA-16b

Duva

GPIIIa / T140I

CD61

Jallu et al, Blood 99:4449-56 (2002)

HPA-17b

Vaa

GPIIIa / T195M

CD61

Kekomaki et al, Transfus Med 2:27-33 (1992)

HPA-18b

Caba

GPIa/ Q716H

CD49b

Bertrand et al, Transfusion 49:2076-83 (2009)

HPA-19b

Sta

GPIIIa / K137Q

CD61

Peterson et al, Transfusion (2009)

HPA-20b

Kno

GPIIb/ T619M

CD41

Peterson et al, Transfusion (2009)

HPA-21b

Nos

GPIIIa/ E628K

CD61

Peterson et al, Transfusion (2009)

HPA-22b

Sey

GPIIb/ K164T

CD41

Peterson et al, Transfusion (2012)

HPA-23b

Hug

GPIIIa/ R622W

CD61

Peterson et al, Transfusion (2012)

HPA-24b

Cab2a+

GPIIb/ S472N

CD41

Jallu et al, Transfusion (2011)

HPA-25b

Swia

GPIa/ T1087M

CD49b

Kroll et al, Transfusion (2011)

HPA-26b

Seca

GPIIIa / K580N

CD61

Sachs et al, Thromb Haemost (2012)

HPA-27b

Cab3a+

GPIIb / L841M

CD41

Jallu et al, Transfusion (2013)

HPA-28b

War

GPIIb / V740L

CD41

Poles et al, Transfusion

HPA-29b

Khab

GPIIIa / T33M†

CD61

Sullivan et al, Transfusion (2015)

HPA-30b

Laba

GPIIb / Q806H

CD41

Wihadmadyatami et al, Transfusion

HPA-31b

Cab4b+

GPIX / P123L

CD42a

Jallu et al, J Thromb Haemost

HPA-32b

Domb

GPIIIa / N174S

CD61

Sullivan et al, Transfusion

HPA-33b

Bla

GPIIIa / D458G

CD61

Poles et al, Transfusion

HPA-34b

Bzha

GPIIIa / R91W

CD61

Bertrand et al, Transfusion

HPA-35b

Efsa

GPIIIa / R479H

CD61

Bertrand et al, Transfusion


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