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Immune-mediated Red Cell Destruction

Versiti’s five Immunohematology Reference Laboratories specialize in evaluation of autoimmune, DAT negative and drug-induced hemolytic anemias.

Immune-mediated Red Cell Destruction

  • Overview

    Immune mediated red cell destruction is caused by the presence of antibodies to the proteins on the surface of the circulating red cell. These antibodies can be caused by an immune response to previously transfused red cells, an autoimmune response against one’s own red cells, or caused be a rare interaction of various drugs and a patient’s red cells. Once an antibody has been formed, a patient may need to receive red cell blood products that are negative for the antigen in question.

  • Approach

    Versiti’s Immunohematology Reference Laboratory provides compatible blood to patients with unique transfusion needs.

    Our labs have earned a reputation for solving transfusion problems associated with the diagnosis of patients who develop hemolysis. We specialize in evaluation of autoimmune, DAT negative and drug-induced hemolytic anemias. Each year we receive samples from throughout the country for detection of drug dependent red cell antibodies and Super Coombs testing.

    Our laboratories are supported in these activities by its stock of rare reagents, skill, special techniques, and high level of training and experience. As an active participant in the American Rare Donor Program, we maintain a large inventory of rare blood at our five locations.

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