Test Information
Genetic analysis is used to diagnose type 2A and 2B VWD in patients with abnormal multimer findings. VWF exon 28 sequence analysis is always performed; if negative, VWD Type 2A Additional Exons is performed at an additional charge.
Additional Test Information
Sample Requirements
Fetal: Amniotic Fluid, CVS, Cultured Amniocytes or Cultured CVS; Parental/Patient: EDTA Whole Blood (lavender top)
Requested Volume
Fetal: 7-15 ml Amniotic Fluid or 5-10 mg CVS, backup culture of Amniocytes or CVS is highly recommended; Two T25 flasks Cultured Amniocytes or CVS (2x10^6 minimum); Parental/Patient: 3-5 ml
Minimum/Pediatric Volume
Fetal: Call Laboratory; Parental/Patient: 2 ml
CPT Codes
Exon 28: 81403; 2A: 81406
Method
PCR and Bi-directional DNA Sequencing