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All of Us

Wisconsin researchers join NIH in launching the All of Us Research Program to advance precision medicine

Milwaukee – May 1, 2018

Three Wisconsin medical and scientific organizations – Marshfield Clinic Research Institute, University of Wisconsin School of Medicine and Public Health, and Froedtert & the Medical College of Wisconsin – in collaboration with the National Institutes of Health (NIH), will open enrollment on May 6 for the All of Us Research Program, a momentous effort to advance individualized prevention, treatment and care for people of all backgrounds.

All of Us is focused on precision medicine, which is an emerging approach to disease treatment and prevention that considers differences in people’s lifestyles, environments and biological makeup, including genes. By partnering with 1 million diverse people who share information about themselves over many years, All of Us will enable research to more precisely prevent and treat a variety of health conditions.

“All of us are unique, but today we live mostly in an era of ‘one-size-fits-all’ medicine,” said Eric Dishman, director of All of Us. “I’m alive today because of precision medicine and I think everyone deserves that same opportunity no matter the color of your skin, your economic status, your age or your sex or gender. In other words, it will truly take all of us.”

Marshfield Clinic Research Institute, University of Wisconsin School of Medicine and Public Health, and Froedtert & the Medical College of Wisconsin (MCW) will partner with BloodCenter of Wisconsin, part of Versiti, and regional Federally Qualified Health Centers (FQHCs) to aid in engagement and recruitment of research participants. BloodCenter of Wisconsin will educate and engage its thousands of blood donors for potential involvement in the program.

People ages 18 and older, regardless of health status, will be able to enroll. Participants are asked to share different types of health and lifestyle information, including through online surveys and electronic health records (EHRs), which will continue to be collected over the course of the program. At different times over the coming months and years, some participants will be asked to visit a local partner site to provide blood and urine samples and to have basic physical measurements taken, such as height and weight. The research program will include communities that have been underrepresented in research to make the program the largest, most diverse resource of its kind.

The Wisconsin program is one of 10 health care provider organizations across the country participating in the research program. It will represent the collaborative efforts of three fully-integrated regional health care systems and the largest provider of blood and blood products in Wisconsin to form a virtual statewide integrated delivery network.

To learn more about All of Us, visit www.JoinAllofUs.org/.

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Additional background information and quotes are enclosed from the institutions partnering to bring All of Us to Wisconsin.

Marshfield Clinic Research Institute

Marshfield Clinic Research Institute, a division of Marshfield Clinic Health System, was founded in 1959. It’s the largest private medical research institute in Wisconsin. The Research Institute consists of research centers in clinical research, cancer research, agricultural health and safety, epidemiology, human genetics, and biomedical informatics. Research Institute investigators publish extensively in peer-reviewed medical and scientific journals addressing a wide range of diseases and other health issues, including cancer, infectious diseases, heart disease, diabetes, eye disease, neurological disease, pediatrics, radiology, women's health, agricultural safety and genetics.

“Marshfield Clinic Research Institute was one of the first in the nation to work on precision medicine in 2002 when it started the Personalized Medicine Research Project, and is now excited to be a leader through the All of Us precision medicine initiative,” said Dr. Murray Brilliant, director of the Marshfield Clinic Research Institute’s Center for Human Genetics, a division of Marshfield Clinic Health System. “We are proud to collaborate with the NIH and our Wisconsin partners on this effort that will dramatically impact medical research for future generations.”

The Health System launched in 2002 its Personalized Medicine Research Project (PMRP), a population-based biobank consisting of genetic information linked to long-term electronic health records from more than 20,000 Health System patients. PMRP was recognized as one of the earliest and most useful biobanks in the U.S. Additionally, the Health System is one of the most productive and earliest adopters of precision medicine. The Health System’s work has been cited by NIH Director Dr. Francis Collins as a model for the federal Precision Medicine Initiative (PMI).

Those interested in participating in All of Us through the Marshfield Clinic Health System should call 888-633-9987 or email allofus@marshfieldresearch.org.

University of Wisconsin School of Medicine and Public Health

The University of Wisconsin School of Medicine and Public Health, in Madison, is the first medical school in the United States to integrate public health into all of its missions, including education. It grants medical, graduate and other health profession degrees. It partners with teaching sites and academic campuses centered in Green Bay, La Crosse, Marshfield, and Milwaukee to enhance the rural and urban educational experiences and service learning opportunities of students across the state of Wisconsin. It has a robust Global Health Program to provide unique learning and service opportunities. The school attracts millions of dollars in basic, clinical, and public health research funding annually and provides a fertile environment for student research. It offers dual degree programs, including M.D./Ph.D. and M.D./M.P.H. integrated training programs.

"All of Us Wisconsin aims to build upon UW researchers' innovative work in precision medicine for cancer treatment to expand the approach to other diseases," said Dr. Marc Drezner, co-principal investigator, All of Us-UW. "We plan to leverage our existing partnerships with Marshfield Clinic, UW Health, and the UW Department of Obstetrics and Gynecology, utilizing sound research and community engagement, to help lay a comprehensive foundation for precision medicine."

In addition, the NIH-funded Clinical and Translational Science Award, held by the University of Wisconsin in partnership with the Marshfield Clinic Health System, has helped support substantial projects in communities throughout Wisconsin. This sets the stage for widespread participation of Wisconsin populations in the All of Us Research Program.

Those interested in participating in All of Us through the University of Wisconsin School of Medicine and Public Health should call 888-294-2662 or email allofus@hslc.wisc.edu.

Medical College of Wisconsin

With a history dating back to 1893, the Medical College of Wisconsin (MCW) is dedicated to leadership and excellence in education, patient care, research and community engagement. More than 1,200 students are enrolled in MCW’s medical school and graduate school programs in Milwaukee, Green Bay, and Central Wisconsin in 2016. MCW’s School of Pharmacy opened in 2017. A major national research center, MCW is the largest research institution in the Milwaukee metro area and second largest in Wisconsin. In FY2016, faculty received more than $184 million in external support for research, teaching, training and related purposes. This total includes highly competitive research and training awards from the National Institutes of Health (NIH). Annually, MCW faculty direct or collaborate on more than 3,100 research studies, including clinical trials. Additionally, more than 1,500 physicians provide care in virtually every specialty of medicine for more than 525,000 patients annually.

“The All of Us Research Program represents an important opportunity for participants to contribute to the research that will guide medical treatment targeted to the uniqueness of individual patients. It is very important that this research is based on the experience of a wide variety of participants. MCW has the unique opportunity to engage populations that have traditionally been underrepresented in biomedical research to further advance patient care in the future through precision medicine,” said Jeffrey Whittle, M.D., professor general internal medicine. “Leading quality precision medicine initiatives such as All of Us, along with our researchers, physicians and partners, helps understand disease, improve diagnosis and advance patient care.”

The Medical College of Wisconsin leads an NIH-funded regional coalition of academic and clinical institutions, the Clinical Translational Science Institute of Southeast Wisconsin, which has been repeatedly cited for its robust community engagement activities. This coalition will facilitate broad participation by all of Milwaukee’s diverse communities. The NIH award represents an opportunity to engage populations that have traditionally been underrepresented in biomedical research.

Those interested in participating in All of Us through Froedtert & the Medical College of Wisconsin should call 414-955-AOUW (2689) or email allofus@mcw.edu.

Froedtert & the Medical College of Wisconsin

The Froedtert & the Medical College of Wisconsin regional health network is a partnership between Froedtert Health and the Medical College of Wisconsin supporting a shared mission of patient care, innovation, medical research and education. Our health network operates eastern Wisconsin's only academic medical center and adult Level I Trauma Center at Froedtert Hospital, Milwaukee, an internationally recognized training and research center engaged in thousands of clinical trials and studies. The Froedtert & MCW health network, which includes five hospitals, one of which is a nationally ranked academic medical center, more than 1,600 physicians and nearly 40 health centers and clinics, draws patients from throughout the Midwest and the nation. In our most recent fiscal year, outpatient visits exceeded 1.1 million, inpatient admissions to our hospitals were 49,250 and visits to our network physicians totaled 932,000. For more information, visit  froedtert.com.

BloodCenter of Wisconsin

BloodCenter of Wisconsin, part of Versiti, is a not-for-profit organization headquartered in Milwaukee, Wisconsin, that specializes in blood services, esoteric diagnostic testing, organ, tissue and stem cell donation, medical services and leading-edge research. We advance patient care by delivering life-saving solutions grounded in unparalleled medical and scientific expertise. The collective efforts of Versiti affiliates result in improved patient outcomes, expanded access to care, and cost efficiencies for health care systems nationwide. For more information, visit www.bcw.edu and www.versiti.org.

“BloodCenter of Wisconsin, part of Versiti, is proud to educate and engage its thousands of blood donors for potential involvement in the All of Us Research Program,” said Dr. Gilbert White, BloodCenter of Wisconsin executive vice president for research. “Precision Medicine is a fast emerging approach to ensuring better outcomes for patients, and it’s an area that BloodCenter is helping to advance by many of our scientists. Participation in this program is one example in which we can contribute to advancing precision medicine in our community and across the nation.”

BloodCenter of Wisconsin’s scientific and medical research discoveries have made tangible contributions to the care of patients since its founding 70 years ago.

Precision Medicine Initiative, PMI, and All of Us are service marks of the U.S. Department of Health and Human Services.

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