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Memorial Sloan Kettering Cancer Center, New York, NY
Brigham and Women's Hospital and Children's Hospital, Boston, MA
Boston University, Boston, MA
My laboratory studies the epigenetic regulation of stem cells and how dysregulation of these pathways contributes to cancer development. Epigenetic mechanisms play an important role in maintaining tissue-specific gene expression patterns and are essential for normal development processes such as hematopoiesis. In normal blood cell development, hematopoietic stem cell (HSC) sits at the top of a hierarchy and has the unique ability to self-renew and differentiate into all blood lineages. HSC self-renewal is tightly controlled and epigenetic regulators play critical roles in this process. In leukemia, cancer cells often harbor multiple genetic mutations that enable them to acquire aberrant self-renewal ability. Recent sequencing of human cancer genome has revealed that mutations in epigenetic regulators commonly occur in leukemia, highlighting their importance in malignancy.
We are interested in understanding the epigenetic regulation of normal and malignant hematopoiesis. We approach this by studying the role of epigenetic regulators in normal and malignant hematopoietic stem cell function. The model systems we use include murine and in vitro model systems. We use techniques such as standard biochemical assays, multi-parameter flow cytometry and genomic and transcriptome profiling by next generation sequencing. We are actively investigating epigenetic factors implicated in acute myeloid leukemia (AML) biology as well as epigenetic regulation of key transcription factors in hematopoiesis.
Jesus Izaguirre Carbonell