Joshua Field, MD, MS

Adult Sickle Cell Disease

• NIH R01 HL095704 (Co-Investigator), Lymphocyte activation in sickle cell lung disease (2010-2015)
• NIH R01 HL098526 (Co-Investigator), Fibrocytes in the pathogenesis of sickle cell lung disease grant (2010–2014)
• NIH R34 HL10875 (Co-PI), Feasibility Study of Regadenoson for the Treatment of Acute Chest Syndrome (2011–2013)
• NIH R01 HL111969 (Co-PI), Biomarkers of Inflammation and Vaso-occlusion in Sickle Cell Disease (2012-2016)
• Doris Duke Charitable Foundation #2011101 (Co-PI), Effects of the Adenosine 2A Receptor Agonist Regadenoson on Sickle Cell Vaso-occlusion and Inflammation (2012–2014)
• NIH P50 HL110790 (Co-PI), A Controlled Clinical Trial of Regadenoson in Sickle Cell Anemia (2012-2017)

Research Coordinators:
Sarah Begghi
Steven Frymark

• Field JJ, Mason P, An P, Kasai Y, McLellan, Jaeger S, Barnes Y, King A, Bessler M, Wilson D. Low Frequency of Telomerase RNA Mutations among Children with Aplastic Anemia or Myelodysplastic Syndrome. Journal of Pediatric Hematology/Oncology, 2006 Jul; 28(7):450-3.
• Field JJ, Giannone L, Bessler M, Blinder M. Immunosuppressive Therapy in Acute Porphyria: Safety and Efficacy in a Patient with Bone Marrow Failure. Pharmacotherapy, 2006; 26(11):1662-6.
• Field JJ, Fenske T, Blinder M. Rituximab for the Treatment of Very High-Titer Acquired Factor VIII Inhibitors Refractory to Conventional Chemotherapy. Haemophilia, 2007; 13: 46-50.
• Goers T, Panepinto J, Blinder M, DeBaun M, Foglia R, Field JJ. Laparoscopic Abdominal Surgery in Children with Sickle Cell Disease is Associated with a Shorter Hospital Stay and Similar Rate of Post-Operative Sickle Cell Disease Complications, Pediatric Blood & Cancer, 2008 Mar;5(3):603-6.
• Du Hy, Pumbo E, Manley P, Field JJ, Bayliss SJ, Wilson DB, Mason PJ, Bessler M.Complex inheritance pattern of dyskeratosis congenita in two families with two different mutations in the telomerase reverse transcriptase gene. Blood, 2008 Feb 1;111(3):1128-30.
• Field JJ, Glassberg J, Gilmore A, Howard J, Patankar S, Eng B, Yan Y, Davis S, DeBaun M, Strunk R. Longitudinal Analysis of Pulmonary Function in Adults with Sickle Cell Disease, American Journal of Hematology, 2008 Jul;83(7):574-6.
• Field JJ, Austin P, An P, Yan Y, DeBaun M. Enuresis is a common and persistent problem among children and young adults with sickle cell anemia, Urology, 2008 Jul;72(1):81-4.
• Jennings J, Ramkumar T, Mao J, Boyd J, Castro M, Field JJ, Strunk R, DeBaun M. Elevated Urinary Leukotriene E Levels are Associated with Hospitalization for Pain in Children with Sickle Cell Disease, American Journal of Hematology, 2008 Aug;83(8):640-3.
• Field JJ, DeBaun M, Yan Y, Strunk R. Growth of Lung Function in Children with Sickle Cell Anemia, Pediatric Pulmonology, 2008 Nov;43(11):1061-6.
• Strunk R, Scott Brown M, Boyd J, Bates P, Field JJ, DeBaun M. Methacholine Challenge in Children with Sickle Cell Disease, a Case Series, Pediatric Pulmonology, 2008 Sep;43(9):924-9.
• Field JJ, Macklin E, YanY, Strunk R, DeBaun M. Sibling History of Asthma is a Risk Factor for Pain in Children with Sickle Cell Anemia, American Journal of Hematology, 2008 Nov;83(11):855-7.
• Frei-Jones M, Field JJ, DeBaun M. Risk Factors for Hospital Readmission Within 30-Days: A New Quality Measure for Children with Sickle Cell Disease, Pediatric Blood and Cancer, 2008 Apr 52(4):481-5.
• Field JJ, Krings J, White NL, Yan Y, Blinder MA, Strunk RC, DeBaun MR. Urinary Cysteinyl Leukotriene E is Associated with Increased Risk for Pain and Acute Chest Syndrome in Adults with Sickle Cell Disease, American Journal of Hematology, 2008 Mar;84(3):158-160
• Field JJ, Strunk RC, Knight-Perry J, Blinder MA, Townsend R, DeBaun MR. Urinary Cysteinyl Leukotriene E Significantly Increases During Pain in Children and Adults with Sickle Cell Disease, American Journal of Hematology, 2009 Apr;84(4):231-3.
• Field JJ, Blinder MA. Sustained Response with Rituximab in Patients with Thrombotic Thrombocytopenia Purpura: a report of 13 cases and review of the literature, American Journal of Hematology, 2009, 84(7):418-21.
• Knight-Perry JE, Field JJ, DeBaun MR, Stocks J, Kirby J, Strunk RC. Hospital Admission for Acute Painful Episode Following Methacholine Challenge in an Adolescent with Sickle Cell Disease, Pediatric Pulmonology, 2009, 44(7):728-30.
• Frei-Jones M, Field JJ, DeBaun M. Multi-modal Intervention and Prospective Implementation of Standardized Sickle Cell Pain Admission Orders Reduces 30-Day Readmission Rate, Pediatric Blood and Cancer, 2009,53(3):401-5.
• Wallace KL, Marshall MA, Ramos SI, Lannigan JA, Field JJ, Strieter RM, Linden J. NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-γ and CXCR3 chemokines. Blood 2009,114(3):667-76.
• Field JJ, Madadi A, Siegel M, Narra V. Pulmonary thrombi are not detected by 3D magnetic resonance angiography in adults with sickle cell anemia and an elevated tricuspid regurgitant jet velocity. American Journal of Hematology 2009; 84(10):686-8 [letter].
• Cohen RT, DeBaun MR, Blinder MA, Strunk RC, Field JJ. Smoking is associated with an increased risk of acute chest syndrome and pain among adults with sickle cell disease. Blood 2010, 115(18): 3852-4.
• Polanowska-Grabowska R, Wallace K, Field JJ, Chen L, Marshall M, Figler R, Gear AR, Linden J. P-selectin mediated platelet neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease. Ateriosclerosis, Thrombosis, and Vascular Biology 2010; 30(12):2392-9.
• Field JJ, Stocks J, Kirkham FJ, Rosen CL, Dietzen DJ, Semon T, Kirkby J, Bates P, Seicean S, DeBaun MR, Redline S, Strunk RC. Airway hyper-responsiveness in children with sickle cell anemia. Chest 2011;139(3):563-8.
• Field JJ, Horst J, Strunk RC, White FV, DeBaun MR. Death due to asthma in two adolescents with sickle cell disease. Pediatr Blood Cancer 2011; 56(3):454-7.
• Cohen R, Madadi A, Blinder MA, DeBaun MR, Strunk RC, Field JJ. Recurrent, severe wheezing is associated with morbidity and mortality in adults with sickle cell disease. Am J Hematol 2011 Sep; 86(9):756-61.
• Knight-Perry J, de las Fuentes L, Waggoner AD, Hoffman RG, Blinder MA, Dávila-Román VG, Field JJ. Abnormalities in Cardiac Structure and Function in Adults with Sickle Cell Disease are not Associated with Pulmonary Hypertension. J Am Soc Echocadiogr 2011 Nov; 24(11):1285-90.
• Field JJ, DeBaun MR.  Acute Chest Syndrome in Adults with Sickle Cell Disease.  In: Schrier S, Mahoney D (eds.) UpToDate: 2012.
• Nathan DG, Field JJ, Lin G, Newberg D, Majerus E, Onyekwere O, Keefer J, Okam M, Ross A, Linden J.  Sickle Cell Disease (SCD), iNKT cells, and regadenoson infusion.  Trans Am Clin Climatol Assoc 2012; 123:312-317.
• Field JJ, Burdick MD, DeBaun MR, Strieter BA, Liu L, Mehrad B, Rose CE, Linder J, Strieter RM. The Role of Fibrocytes in Sickle Cell Lung Disease. PLosOne 2012, 7(3):e33702.
• Keeley EC, Mehrad B, Janardhanan R, Salerno M, Hunter J, Burdick MM, Field JJ, Strieter R, Kramer C.  Elevated Circulating Fibrocyte Levels in Subjects with Hypersensitive Heart Disease.  Journal of Hypertension  2012, 30(9):1856-61.
• Field JJ*, Lin G*, (*co-first authors), Okam MM, Majerus E, Keefer J, Onyekwere O, Ross A, Campigotto F, Neuberg D, Linden J*, Nathan DG* (*co-senior authors).  Sickle Cell Vaso-Occlusion Causes Activation on iNKT Cells that is Decreased by the Adenosine A_2A Receptor Agonist Regadenoson.  Blood 2013, 121(17):3329-34.
• Cohen RT, Strunk RC, Field JJ, Rosen CL, Kirkham FJ, Redline S, Stocks J, Rodeghier MJ, DeBaun MR.  Environmental Tobacco Smoke and Airway Obstuction in Children with Sickle Cell Anemia.  Chest  2013, 144(4):1323-1329.
• Blinder MA, Geng B, Lisker-Melman M, Crippin JS, Korenblat K, Chapman W, Shenoy S, Field JJ. Successful oprthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature.  Hematol Rep 2013 5(1):1-4.
• Field JJ.  Sickle cell disease: new treatments and their rationale.  Clin Adv Hematol Oncol. 2013; 11(11):740-743.
• Linden J, Lin G, Yu J, Neuberg D, Nathan D, Field JJ.  NF-kB Activation Mediates Induction of Anti-Inflammatory Adenosine A₂A Receptors in iNKT Cells of Sickle Cell Patients During Vaso-Occlusive Episodes and Upon Activation of Cultured Human iNKT Cells (American Society of Hematology), 2013.
• Lin G, Yu J, Field JJ, Nathan D, Linden J.  Human Sickle Cell Disease Increases Numbers and Activation of Peripheral Blood Myeloid Dendritic Cells, Monocytes, and Neutrophils (American Society of Hematology), 2013
• Field JJ, Nathan DG, Linden J.  The Role of Adenosine Signaling in Sickle Cell Therapeutics.  Hematol Oncol Clin North Am 2013, in press.
• Lin G*, Field JJ* (co-first authors), Yu JC, Ken R, Neuberg D, Nathan DG, Linden J.  NF-kB is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid iduction of adenosine A_2A receptors.  PLoSOne 2013, accepted.
• Lin G, Yu J, Field JJ, Nathan D, Linden J.  Human Sickle Cell Disease increases numbers and activation of peripheral blood myeloid dendritic cells, monocytes, and neutrophils (American Society of Hematology), 2013.
• Field JJ. A Phase I single ascending dose study of NKTT120 in stable adult sickle cell patients (American Society of Hematology), 2013.
• Yu J, Lin G, Ken R, Field JJ, Linden J.  The role of NF-kB in the activation of human iNKT cells in sickle cell disease patients and in vitro (Amerian Society of Hematology), 2013.
• Koch K, Leonard C, Bagemihl K, Marks D, Abshire T, Field JJ.  An intensive model of care for adults with sickle cell disease that rapidly reduces hospital admissions, readmissions and cost (American Society of Hematology, 2013).  [Oral Presentation.]