Platelet Antigen Database

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Human Platelet Antigen (HPA) Database

This database serves as the principal site for cataloging the current list of human platelet allo-antigens (HPA). To submit data and obtain confirmation and numbering of newly discovered HPA by the International Platelet Immunology Nomenclature Committee of the International Society of Blood Transfusion (ISBT), please use the official forms and instructions on this page.

Alloantibodies against HPA are the cause of several immune platelet disorders, including fetal and neonatal alloimmune thrombocytopenia (FNAIT) and platelet transfusion refractoriness (PTR). Detection and identification of HPA alloantibodies is critical in making a proper diagnosis and for ensuring appropriate patient care.

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HPA Database

Use the database below to search for any of the current 35 recognized human platelet antigens. Search by number, 1-35 to jump to a specific antigen.

System	Antigen	Original Names	Glycoprotein	CD	Reference
HPA-1	HPA-1a HPA-1b	Zw^a, Pl^A1 Zw^b,PI^A2	GPIIIa / †p.L33P	CD61	van Loghem et al, Vox Sang 4:161-9 (1959) Shulman et al, J Clin Invest 40:1597-1620 (1961) van der Weerdt et al, Vox Sang 8:513-30 (1963)
HPA-2	HPA-2a HPA-2b	Ko^b Ko^a, Sib^a	GPIbα / p.T145M	CD42b	van der Weerdt et al, Proc. 8th Congress European Society of Haematology, Vienna 1961. Karger, Basel .P379 van der Weerdt Thesis 1965, University of Amsterdam
HPA-3	HPA-3a HPA-3b	Bak^a, Lek^a Bak^b	GPIIIa	CD61	von dem Borne et al, Vox Sang 39:113-20 (1980) Kickler et al, Blood 71:894-8 (1988)
HPA-4	HPA-4a HPA-4b	Yuk^b, Pen^a Yuk^a, Pen^b	GPIIIa / p.R143Q	CD61	Friedman et al, Blood 65:1412-5 (1985) Shibata et al, Vox Sang 50:177-80 (1986) Shibata et al, Vox Sang 51:334-6 (1986)
HPA-5	HPA-5a HPA-5b	Br^b, Zav^b Br^a, Zav^a, Hc^a	GPIa / p.E505K	CD49b	Kiefel et al, Vox Sang 54:101-6 (1998) Kiefel et al, Blood 73:2219-23 (1989) Santoso et al, Br J Haematol 72:191-8 (1989)
	HPA-6b	Ca^a, Tu^a	GPIIIa / R489Q	CD61	Kekomaki et al, Br J Haematol 83:306-10 (1993) McFarland et al, Blood 81:3318-23 (1993)
	HPA-7b	Mo^a	GPIIIa / P407A	CD61	Kuijpers et al, Blood 81:70-6 (1993)
	HPA-8b	Sr^a	GPIIIa / R636C	CD61	Kroll et al, Blood 76:2296-302 (1990)
	HPA-9b	Max^a	GPIIb / V837M	CD41	Noris et al, Blood 86:1019-26 (1995)
	HPA-10b	La^a	GPIIIa / R62Q	CD61	Peyruchaud et al, Blood 89:2422-8 (1997)
	HPA-11b	Gro^a	GPIIIa / R633H	CD61	Simsek et al, Vox Sang 67:302-6 (1994)
	HPA-12b	Iy^a	GPIbβ / G15E	CD42c	Kiefel, et al, Vox Sang 69:250-4 (1995)
	HPA-13b	Sit^a	GPIIIa / K611del	CD49b	Santoso et al, Blood 94:4103-11 (1999)
	HPA-14b	Oe^a	GPIIIa / K611del	CD61	Santoso et al, Blood 99:1205-14 (2002)
HPA-15	HPA-15a HPA-15b	Gov^b Gov^a	CD109 / S682Y	CD109	Kelton et al, Blood 75:2172-6 (1990) Smith et al, Blood 86:2807-14 (1995)
	HPA-16b	Duv^a	GPIIIa / T140I	CD61	Jallu et al, Blood 99:4449-56 (2002)
	HPA-17b	Va^a	GPIIIa / T195M	CD61	Kekomaki et al, Transfus Med 2:27-33 (1992)
	HPA-18b	Cab^a	GPIa/ Q716H	CD49b	Bertrand et al, Transfusion 49:2076-83 (2009)
	HPA-19b	Sta	GPIIIa / K137Q	CD61	Peterson et al, Transfusion (2009)
	HPA-20b	Kno	GPIIb/ T619M	CD41	Peterson et al, Transfusion (2009)
	HPA-21b	Nos	GPIIIa/ E628K	CD61	Peterson et al, Transfusion (2009)
	HPA-22b	Sey	GPIIb/ K164T	CD41	Peterson et al, Transfusion (2012)
	HPA-23b	Hug	GPIIIa/ R622W	CD61	Peterson et al, Transfusion (2012)
	HPA-24b	Cab2^a+	GPIIb/ S472N	CD41	Jallu et al, Transfusion (2011)
	HPA-25b	Swi^a	GPIa/ T1087M	CD49b	Kroll et al, Transfusion (2011)
	HPA-26b	Sec^a	GPIIIa / K580N	CD61	Sachs et al, Thromb Haemost (2012)
	HPA-27b	Cab^3a+	GPIIb / L841M	CD41	Jallu et al, Transfusion (2013)
	HPA-28b	War	GPIIb / V740L	CD41	Poles et al, Transfusion
	HPA-29b	Kha^b	GPIIIa / T33M†	CD61	Sullivan et al, Transfusion (2015)
	HPA-30b	Lab^a	GPIIb / Q806H	CD41	Wihadmadyatami et al, Transfusion
	HPA-31b	Cab4^b+	GPIX / P123L	CD42a	Jallu et al, J Thromb Haemost
	HPA-32b	Dom^b	GPIIIa / N174S	CD61	Poles et al, Transfusion
	HPA-33b	Bl^a	GPIIIa / D458G	CD61	Poles et al, Transfusion
	HPA-34b	Bzh^a	GPIIIa / R91W	CD61	Bertrand et al, Transfusion
	HPA-35b	Efs^a	GPIIIa / R479H	CD61	Bertrand et al, Transfusion

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