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Human Platelet Antigen (HPA) Database

The database provides a centralized repository for discovered and known human platelet antigens.

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Human Platelet Antigen (HPA) Database


This database serves as the principal site for cataloging the current list of human platelet allo-antigens (HPA). To submit data and obtain confirmation and numbering of newly discovered HPA by the International Platelet Immunology Nomenclature Committee of the International Society of Blood Transfusion (ISBT), please use the official forms and instructions on this page.

Alloantibodies against HPA are the cause of several immune platelet disorders, including fetal and neonatal alloimmune thrombocytopenia (FNAIT) and platelet transfusion refractoriness (PTR). Detection and identification of HPA alloantibodies is critical in making a proper diagnosis and for ensuring appropriate patient care.

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Use the database below to search for any of the current 35 recognized human platelet antigens. Search by number, 1-35 to jump to a specific antigen.

System Antigen Original Names Glycoprotein CD Reference
HPA-1

HPA-1a
HPA-1b

Zwa, PlA1 Zwb,PIA2

GPIIIa /L33P

CD61

van Loghem et al, Vox Sang (1959)
Shulman et al, J Clin Invest (1961)
van der Weerdt et al, Vox Sang (1963)

HPA-2

HPA-2a
HPA-2b

Kob Koa, Siba

GPIbα / T145M

CD42b

van der Weerdt et al, (1969)
van der Weerdt, (1965)

HPA-3

HPA-3a
HPA-3b

Baka, Leka Bakb

GPIIIb / I8435

CD41

von dem Borne et al, Vox Sang (1980)
Kickler et al, Blood (1988)

HPA-4

HPA-4a
HPA-4b

Yukb, Pena
Yuka, Penb

GPIIIa / R143Q

CD61

Friedman et al, Blood (1985)
Shibata et al, Vox Sang (1986)
Shibata et al, Vox Sang (1986)

HPA-5

HPA-5a
HPA-5b

Brb, Zavb
Bra, Zava, Hca

GPIa / E505K

CD49b

Kiefel et al, Vox Sang (1988)
Kiefel et al, Blood (1989)
Santoso et al, Br J Haematol (1989)

HPA-6b

Caa, Tua

GPIIIa / R489Q

CD61

Kekomäki et al, Br J Haematol (1993)
McFarland et al, Blood (1993)

HPA-7b

Moa

GPIIIa / P407A

CD61

Kuijpers et al, Blood (1993)

HPA-8b

Sra

GPIIIa / R636C

CD61

Kroll et al, Blood (1990)

HPA-9b

Maxa

GPIIb / V837M

CD41

Noris et al, Blood (1995)

HPA-10b

Laa

GPIIIa / R62Q

CD61

Peyruchaud et al, Blood (1997)

HPA-11b

Groa

GPIIIa / R633H

CD61

Simsek et al, Blood (1994)

HPA-12b

Iya

GPIbβ / G15E

CD42c

Kiefel et al, Vox Sang (1995)

HPA-13b

Sita

GPIIIa / K611del

CD49b

Santoso et al, Blood (1999)

HPA-14b

Oea

GPIIIa / K611del

CD61

Santoso et al, Blood (2002)

HPA-15

HPA-15a
HPA-15b

Govb
Gova

CD109 / S682Y

CD109

Kelton et al, Blood (1990)
Smith et al, Blood (1995)

HPA-16b

Duva

GPIIIa / T140I

CD61

Jallu et al, Blood (2002)

HPA-17b

Vaa

GPIIIa / T195M

CD61

Kekomäki et al, Trasfus Med (1992)

HPA-18b

Caba

GPIa/ Q716H

CD49b

Bertrand et al, Transfusion (2009)

HPA-19b

Sta

GPIIIa / K137Q

CD61

Peterson et al, Transfusion (2010)

HPA-20b

Kno

GPIIb/ T619M

CD41

Peterson et al, Transfusion (2010)

HPA-21b

Nos

GPIIIa/ E628K

CD61

Peterson et al, Transfusion (2010)

HPA-22b

Sey

GPIIb/ K164T

CD41

Peterson et al, Transfusion (2012)

HPA-23b

Hug

GPIIIa/ R622W

CD61

Peterson et al, Transfusion (2012)

HPA-24b

Cab2a+

GPIIb/ S472N

CD41

Jallu et al, Transfusion (2011)

HPA-25b

Swia

GPIa/ T1087M

CD49b

Kroll et al, Transfusion (2011)

HPA-26b

Seca

GPIIIa / K580N

CD61

Sachs et al, Thromb Haemost (2012)

HPA-27b

Cab3a+

GPIIb / L841M

CD41

Jallu et al, Transfusion (2013)

HPA-28b

War

GPIIb / V740L

CD41

Poles et al, Transfusion (2013)

HPA-29b

Khab

GPIIIa / T33M†

CD61

Sullivan et al, Transfusion (2015)

HPA-30b

Laba

GPIIb / Q806H

CD41

Wihadmadyatami et al, Transfusion (2015)

HPA-31b

Cab4b+

GPIX / P123L

CD42a

Jallu et al, J Thromb Haemost (2017)

HPA-32b

Domb

GPIIIa / N174S

CD61

Sullivan et al, Transfusion (2017)

HPA-33b

Bla

GPIIIa / D458G

CD61

Poles et al, Transfusion (2019)

HPA-34b

Bzha

GPIIIa / R91W

CD61

Bertrand et al, Transfusion (2019)

HPA-35b

Efsa

GPIIIa / R479H

CD61

Bertrand et al, Transfusion (2019)


Please use the following format to cite this website for publication purposes: Versiti (October, 2020). HPA Database. Retrieved from https://www.versiti.org/hpa.

Versiti provides the information on this website “as is, where is” and without any representations or warranties. Versiti is not providing any medical advice, diagnosis or treatment through this website. The content contained on the website is to educate users of various issues. Nothing in the content is intended to serve or be used as a substitute for professional medical or other professional advice. There is no assurance that the content contains the most up-to-date or useful information for any person. Nothing set forth in this website is represented or warranted to be safe or effective for you or any person. Users should contact their health care provider before relying on information on this website.

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