Human Leukocyte Antigen (HLA) Typing

Versiti’s comprehensive transplant services support solid organ transplantation, stem cell transplantation and cellular therapy.

Human Leukocyte Antigen (HLA) Typing


Versiti Diagnostic Laboratories’ state-of-the-art Histocompatibility Lab is designed to support solid organ and stem cell transplant programs through human leukocyte antigen (HLA) typing. Our transplant support team is built on forming strong relationships with our clinical partners and becoming part of the patient care team. Our combination of meticulous laboratory practices, skilled technical staff and expert directors offer personal clinical consultation to make the Histocompatibility Lab a leader in transplant support.

The Versiti transplant portfolio includes:

  • Histocompatibility and Immunogenetics testing services
  • Infectious disease marker testing
  • Post-transplant monitoring
  • Tissue services
  • Apheresis hematopoietic progenitor cell collections
  • More than 3,500 transplant-ready, high cell-count cord blood units
  • Organ procurement organization
 

  • HLA panel by NGS includes all relevant HLA loci, leading to better matched donors
  • Sensitivity of post-transplant monitoring enables early detection of disease relapse

  • Consulting on cases to find the best donor match for patients
  • Providing education, including new testing and transplant topics

  • Our comprehensive human leukocyte antigen testing can lead to faster identification of donors
  • We provide transplant centers with innovative solutions and consultation

  • HLA Class I and Class II typing to help identify the best available donor for a patient in need of a solid organ transplant
  • Testing to detect and identify antibodies to HLA Class I and Class II antigens to help identify the best donor for a patient with pre-formed HLA antibodies
  • Crossmatching to confirm donor and patient compatibility

  • High-resolution typing by NGS for HLA Class I and Class II to help identify the best available donor for a patient in need of a stem cell transplant
  • Unique related donor HLA haplotype screening by short tandem repeat (STR) assay
  • Expert HLA antibody identification and monitoring for sensitized patients and haploidentical transplants
  • KIR genotyping to aid in selection of the best donor for particular cases
  • Post-transplant chimerism testing for engraftment and relapse monitoring
  • HLA Loss of Heterozygosity (LOH) for post-transplant relapse characterization
  • Erythroid chimerism test to monitor sickle cell disease transplant patients
  • AML companion diagnostic testing offering high sensitivity and fast turnaround time

  • Expert nurses available 24/7 to perform therapeutic apheresis procedures
  • Leaders in stem cell collection support

Versiti Blood Center of Indiana’s ASHI-accredited HLA lab provides testing necessary to support patients who need specialty platelets due to refractoriness to platelet transfusions. Services include:

  • HLA and solid phase red cell adherence (SPRCA) matched platelets
  • HLA Class I antibody and antigen determinations
  • TRALI screening for blood donors
  • HLA/HPA patient matching
  • Parathyroid tissue cryopreservation

HLA matched platelets can be sent anywhere in the U.S. for refractory and difficult-to-match patients, as needed.

  • Indiana HLA Hematology Order Form
  • Indiana HLA TRALI Screen Order Form

Versiti Blood Center of Michigan’s specialized HLA lab offers tissue typing by DNA methods used in donor and patient transplant matching; evaluates disease associations; and finds HLA-matched platelet products for patients with special needs.

Forms:
  • HLA Laboratory – Special Order Apheresis Platelets Request
  • Human Leukocyte Antigen (HLA) Testing Request
BMT Requests:
  • BMT Infusion Request
  • PBSC Lymphocyte Collection and Processing Order
  • Statement of Donor Eligibility
  • Statement of Urgent Medical Need Ineligible Donor
  • Statement of Urgent Need HPC Product with Positive Culture Results
  • Infectious Disease Marker (IDM) Testing
  • Order to Release Cryopreserved Products – Fillable
  • Statement of Urgent Medical Need Donor with Incomplete Eligibility Determination
  • Imported Product Request Order
  • Outpatient BMT PBSC Orders
  • Unpacking and Storing CBU at Hospital
 
Chimerism Testing for Engraftment
Among Versiti Diagnostic Labs’ transplant testing menu is chimerism testing for post-transplant and cellular therapy patients.
 
HLA Loss of Heterozygosity
Versiti Diagnostic Labs’ Histocompatibility laboratory conducts an HLA loss of heterozygosity evaluation for post-transplant relapse patients.
 
Molecular Oncology Testing
Molecular oncology lab tests to help diagnose blood cancers like acute myeloid leukemia, chronic myelogenous leukemia and more.
 
Specialty Products & Services
Versiti offers a number of specialty products and services, including matched platelets, autologous and directed donations, and therapeutic phlebotomy.