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Each publication represents collaborative discovery shared with the global research community. We publish breakthrough findings that accelerate progress toward better treatments worldwide. VBRI investigators publish in leading journals, including Nature, Science, Cell, Blood, and the New England Journal of Medicine—reaching global audiences of researchers and clinicians.

Atypical memory B-cell clonal expansion and inflammatory programs associate with platelet-activating antibody development in COVID-19

Researchers at the Versiti Blood Research Institute and Medical College of Wisconsin have identified key immune system features that may explain why some COVID-19 patients develop antibodies that cause dangerous blood clots. Using advanced genetic sequencing technology, the team found that patients who developed these harmful antibodies showed signs of a heightened inflammatory response, with a specific population of immune cells, atypical memory B-cells, playing a central role. These cells carried structural signatures previously linked to clot-promoting antibodies in both COVID-19 and a related clotting disorder. Published in JCI Insight, this study offers the most detailed look yet at how these dangerous antibodies develop, and may open the door to new strategies for preventing life-threatening clotting complications in COVID-19 and beyond.

Witman N, Yu M, Zhang Y, Gai K, Chen Y, Zhou L, Nguyen C, Zhu W, Zheng Y, Jobe SM, Graham MB, Cui W, Wang D, Wen R. Atypical memory B-cell clonal expansion and inflammatory programs associate with platelet-activating antibody development in COVID-19. JCI Insight. 2026 Feb 26:e201033. doi: 10.1172/jci.insight.201033. Epub ahead of print. PMID: 41746733.

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Publication List

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  • Yu JF, Zheng S, Yu C, Gao S, Shen Z, Nar R, Huang S, Wu L, Gu Ta, Qian Z. KRAS mutants confer platinum resistance by hijacking ALKBH5 post-translational modifications–mediated DNA damage response in lung cancer. J Clin Invest. 2025;135(6).
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  • Chen Z, Zheng Q, Wang Y, An X, Yirga SK, Lin D, Shi Q, Huang M, Chen Y. CXCL13/CXCR5 axis facilitates TFH expansion and correlates with disease severity in adults with immune thrombocytopenia. Thromb Res. 2024;244:109196.
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  • Yang M, Silverstein RL. Targeting Cysteine Oxidation in Thrombotic Disorders. Antioxidants. 2024;13(1):83.
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  • Zhang Z, Rodriguez M, Zheng Z. Clot or Not? Reviewing the Reciprocal Regulation Between Lipids and Blood Clotting. Arterioscler Thromb Vasc Biol. 2024;44(3):533-544.
  • Heng Zhang, Zhengli Wang, Huong T.T. Nguyen, Abigail J. Watson, Qifang Lao, An Li, and Jieqing Zhu. Integrin α5β1 contributes to cell fusion and inflammation mediated by SARS-CoV-2 spike via RGD-independent interaction. Proc Natl Acad Sci USA. 2024.

  • Zhang Y, Lin D, Zheng Y, Chen Y, Yu M, Cui D, Huang M, Su X, Sun Y, Chen Y, Qian Z, Carlson KS, Wen R, Wang D. MiR-9-1 controls osteoblastic regulation of lymphopoiesis. Leukemia. 2023;37(11):2261-2275.
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  • Zheng Y, Yu M, Chen Y, Xue L, Zhu W, Fu G, Morris SW, Wen R, Wang D. CARD19, a Novel Regulator of the TAK1/NF-κB Pathway in Self-Reactive B Cells. J Immunol. 2023;210(9):1222-1235.
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  • Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J. Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice. Leukemia. 2023;36(4):1167-1170.
  • Bluemn T, Schmitz J, Zheng Y, Burns R, Zheng S, DeJong J, Christiansen L, Arnold O, Izaguirre-Carbonell J, Wang D, Deshpande AJ, Zhu N. Differential roles of BAF and PBAF subunits, Arid1b and Arid2, in MLL-AF9 leukemogenesis. Leukemia. 2023;36(4):946-955.
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  • Zheng Y, Yu M, Chen Y, Xue L, Zhu W, Fu G, Morris SW, Wen R, Wang D. CARD19, a Novel Regulator of the TAK1/NF-κB Pathway in Self-Reactive B Cells. J Immunol. 2023;210:1222-1235.
  • Kanack AJ, Schaefer JK, Sridharan M, Splinter NP, Kohlhagen MC, Singh B, De Lorenzo SB, Mauch EE, Hussein MA, Shaikh M, Kumar S, Wen R, Wang D, Murray D, Padmanabhan A. Monoclonal gammopathy of thrombotic/thrombocytopenic significance. Blood. 2023;141:1772-1776.
  • Dai W, Castleberry M, Zheng Z. Tale of two systems: the intertwining duality of fibrinolysis and lipoprotein metabolism. J Thromb Haemost. 2023;21(10):2679-2696.
  • Dai W, Zhang H, Lund H, Zhang Z, Castleberry M, Rodriguez M, Kuriakose G, Gupta S, Lewandowska M, Powers HR, Valmiki S, Zhu J, Shapiro AD, Hussain MM, López JA, Sorci-Thomas MG, Silverstein RL, Ginsberg HN, Sahoo D, Tabas I, Zheng Z. Intracellular tPA-PAI-1 interaction determines VLDL assembly in hepatocytes. Science. 2023;381(6661):eadh5207.
  • Rodriguez M, Dai W, Lund H, Osinski K, Zhang Z, Silverstein RL, Zheng Z. The correlations among racial/ethnic groups, hypertriglyceridemia, thrombosis, and mortality in hospitalized patients with COVID-19. Best Pract Res Clin Haematol. 2023.
  • Heng Zhang, Daniel S. Zhu, and Jieqing Zhu. Family-wide analysis of integrin structures predicted by AlphaFold2. Comput Struct Biotechnol J. 2023;21:4497-4507.
  • Koukouritaki SB, Thinn AMM, Ashworth KJ, Fang J, Slater HS, Du LM, Pillois X, Nurden AT, Di Paola J, Jieqing Zhu, Wilcox DA. A single F153Sβ3 mutation causes constitutive integrin αIIbβ3 activation in a variant form of Glanzmann thrombasthenia. Blood Adv. 2023;7(13):3180-3191.

  • Newman DK, Newman PJ. Antigen-specific immunotherapy for platelet alloimmune disorders. Hum Immunol. 2022.
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  • Zhang N, Lin S, Cui W, Newman PJ. Overlapping and unique substrate specificities of ST3GAL1 and 2 during hematopoietic and megakaryocytic differentiation. Blood Adv. 2022;6(13):3945-3955.
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  • Moroi AJ, Newman PJ. Conditional CRISPR-mediated deletion of Lyn kinase enhances differentiation and function of iPSC-derived megakaryocytes. J Thromb Haemost. 2022;20(1):182-195.
  • Zhi H, Ahlen MT, Skogen B, Newman DK, Newman PJ. Preclinical evaluation of immunotherapeutic regimens for fetal/neonatal alloimmune thrombocytopenia. Blood Adv. 2022;5(18):3552-3562.
  • Rao S, Broglie L. HSCT for adults with immunodeficiencies. Blood. 2022;140(14):1580-1581.
  • Pommert L, Schafer ES, Malvar J, Gossai N, Florendo E, Pulakanti K, Heimbruch K, Stelloh C, Chi YY, Sposto R, Rao S, Huynh VT, Brown P, Chang BH, Colace SI, Hermiston ML, Heym K, Hutchinson RJ, Kaplan JA, Mody R, O'Brien TA, Place AE, Shaw PH, Ziegler DS, Wayne A, Bhojwani D, Burke MJ. Decitabine and vorinostat with FLAG chemotherapy in pediatric relapsed/refractory AML. Am J Hematol. 2022;97(5):613-622.
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  • Shi Q, Fahs SA, Matterson JG, Yu H, Perry C, Morateck PA, Schroeder JA, Rapten J, Weiler H, Montgomery RR. A novel mouse model of type 2N VWD recapitulates human VWD. Blood Adv. 2022;6(9):2778-2790.
  • Shi Q, Weiler H. Blocking hemophilic arthropathy. Blood. 2022;139(18):2735.
  • Cai Y, Schroeder JA, Jing W, Yu H, Gurski C, Williams CB, Wang S, Dittel BN, Shi Q. Targeting transmembrane-domain-less MOG expression to platelets prevents disease development in EAE. Front Immunol. 2022;13:1029356.
  • Luo L, Zheng Q, Chen Z, Huang M, Fu L, Hu J, Shi Q, Chen Y. Hemophilia A patients with inhibitors: mechanistic insights and novel therapeutic implications. Front Immunol. 2022;13:1019275.
  • Chen Y, Luo L, Zheng Y, Zheng Q, Zhang N, Gan D, Yirga SK, Lin Z, Shi Q, Fu L, Hu J. Association of Platelet Desialylation and Circulating TFH Cells. Front Immunol. 2022;13:810620.
  • Dai W, Lund H, Chen Y, Zhang J, Osinski K, Jones SZ, Kreuziger LB, López JA, Benjamin IJ, Silverstein RL, Zheng Z. Hypertriglyceridemia during hospitalization associates with mortality in COVID-19. J Clin Lipidol. 2022;15(5):724-731.
  • Zheng Z, Riva N, Scarlatescu E, de Moerloose P, Ariëns R, Amigo MC. Developing and improving the ethical framework for the ISTH. J Thromb Haemost. 2022;20(8):1753-1754.
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  • Shi H, Wang X, Li F, Gerlach BD, Yurdagul A Jr, Moore MP, Zeldin S, Zhang H, Cai B, Zheng Z, Valenti L, Tabas I. CD47-SIRPα axis blockade in NASH decreases hepatic fibrosis. Sci Transl Med. 2022;14(672).
  • Heng Zhang, Qifang Lao, Jue Zhang, Jieqing Zhu. Coagulopathy in COVID-19 and anticoagulation clinical trials. Best Pract Res Clin Haematol. 2022;35(3):101377.
  • Fu-Yang Lin, Jing Li, Yonghua Xie, Jianghai Zhu, Nguyen TTH, Yonghui Zhang, Jieqing Zhu, Timothy A. Springer. A general chemical principle for creating closure-stabilizing integrin inhibitors. Cell. 2022;185(19):3533-3550.
  • Yang M, Silverstein RL. Targeting Cysteine Oxidation in Thrombotic Disorders. Antioxidants. 2022.
  • Huang W, Li R, Zhang J, Chen Y, Ramakrishnan DP, Silverstein RL. CD36 transmembrane domain peptide interrupts CD36 interactions and inhibits atherogenic functions. Transl Res. 2022.

  • Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Karin M, Sanchez-Lopez E. Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity. 2021; PMID: 34115964. doi:10.1016/j.immuni.2021.05.004.
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  • Rodriguez M, Dai W, Lund H, Osinski K, Zhang Z, Silverstein R, Zheng Z. The correlations among racial/ethnic groups, hypertriglyceridemia, thrombosis, and mortality in hospitalized patients with COVID-19. Best Pract Res Clin Haematol. 2022 Sep;35(3):101386. doi: 10.1016/j.beha.2022.101386. Epub 2022 Oct 3. PMID: 36494155
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  • Dyer MR, Alexander W, Hassoune A, Chen Q, Alvikas J, Liu Y, Haldeman S, Plautz W, Loughran P, Li H, Boone B, Sadovsky Y, Sundd P, Zuckerbraun BS, Neal MD. Platelet-derived extracellular vesicles released after trauma promote hemostasis but contribute to DVT in mice. J Thromb Haemost. 2019 Oct;17(10):1733-1745. PubMed PMID: 31294514; PubMed Central PMCID: PMC6773503.
  • Sundd P, Gladwin MT and Novelli EM. Pathophysiology of sickle cell disease. Annu Rev Pathol. 2019 Jan 24;14:263-292. PubMed PMID: 30332562; PubMed Central PMCID: PMC7053558.
  • Pradhan‐Sundd T, Kosar K, Saggi H, Zhang R, Vats R, Cornuet P, Green S, Singh S, Zeng G, Sundd P, Nejak-Bowen K. Wnt/β-catenin signaling plays a protective role in the mdr2 ko murine model of cholestatic liver disease. Hepatology. 2019 Sep 6. doi: 10.1002/hep.30927. PubMed PMID: 31489648.
  • Gu T, Fields AT, Cornuet P, Zhu J, Aster R, White GC, Wen R. Prothrombotic antibodies targeting the spike protein’s receptor-binding domain in severe COVID-19. Blood. 2019; (preprint/accepted entry as listed in source file).
  • Zheng Z, Nakamura K, Gershbaum S, Wang X, Thomas S, Bessler M, Schrope B, Krikhely A, Liu RM, Ozcan L, López JA, Tabas I. An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1. Blood. 2019 Feb 14;133(7):743-753. doi: 10.1182/blood-2018-07-864843. Epub 2018 Dec 1. PMID: 30504459
  • Giordano L, Gregory AD, Pérez Verdaguer M, Ware SA, Harvey H, DeVallance E, Brzoska T, Sundd P, Zhang Y, Sciurba FC, Shapiro SD, Kaufman BA. Extracellular Release of Mitochondrial DNA: Triggered by Cigarette Smoke and Detected in COPD. Cells. 2019; PMID: (as listed in source file).
  • Zorn KE, Cunningham AM, Meyer AE, Carlson KS, Rao S. Pediatric myeloid sarcoma: clinical presentations, significance, and biology. (2019 entry as listed in source file).
  • (Additional 2019 publications captured from the uploaded file appear below, unchanged from source formatting.)
  • Perkins LA, Nyiranshuti L, Little-Ihrig L, Latoche JD, Day KE, Zhu Q, Tavakoli S, Sundd P, Novelli EM, Anderson CJ. Integrin VLA-4 as a PET imaging biomarker of hyper-adhesion in transgenic sickle mice. Blood Adv. 2019 Sep 8;4(17):4102-4112. doi: 10.1182/bloodadvances.2020002642. PubMed PMID: 32882004; PubMed Central PMCID: PMC7479956.
  • Crompton D, Gudla S, Waters JH, Sundd P, Kameneva MV. Hemorheological Approach to Improve Perfusion of Red Blood Cells with Reduced Deformability Using Drag-Reducing Polymer (In Vitro Study). ASAIO J. 2019; (as listed in source file).
  • Zhao J, Florentin J, Tai YY, Torrino S, Ohayon L, Brzoska T, Tang Y, Yang J, Negi V, Woodcock CC, Risbano MG, Nouraie SM, Sundd P, Bertero T, Dutta P, Chan SY. Long Range Endocrine Delivery of Circulating miR-210 to Endothelium Promotes Pulmonary Hypertension. Circ Res. 2019; (as listed in source file).

  • Pradhan-Sundd T, Zhou L, Vats R, Jiang A, Molina L, Singh S, Poddar M, Russell JM, Stolz DB, Oertel M, Apte U, Watkins S, Ranganathan S, Nejak-Bowen KN, Sundd P, Pal Monga S. Dual catenin loss in murine liver causes tight junctional deregulation and progressive intrahepatic cholestasis. Hepatology. 2018 Jun;67(6):2320-2337. doi: 10.1002/hep.29585. PubMed PMID: 29023813; PubMed Central PMCID: PMC5893443.
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  • Dongwen Zhou, Aye Myat Myat Thinn, Yan Zhao, Zhengli Wang, and Jieqing Zhu. Structure of an extended β3 integrin. Blood, 132(9): 962-972 (2018).
  • Aye Myat Myat Thinn, Zhengli Wang, and Jieqing Zhu. The membrane distal regions of integrin α cytoplasmic domains contribute differently to integrin inside-out activation. Scientific Reports, 8(1): 5067 (2018).
  • Jieqing Zhu. Csk/CD148 and platelet SFK activation – a balancing act! Blood, 131(10):1042-1043 (2018).
  • CBFβ-SMMHC inhibition triggers apoptosis by disrupting MYC chromatin dynamics in acute myeloid leukemia.
  • Lendermon EA, Dodd-O JM, Coon TA, Wang X, Ensor CR, Cardenes N, Koodray CL, Heusey HL, Bennewitz MF, Sundd P, Bullock GC, Popescu I, Guo L, O'Donnell CP, Rojas M, McDyer JF. Azithromycin Fails to Prevent Accelerated Airway Obliteration in T-bet-/- Mouse Lung Allograft Recipients. Transplant Proc. 2018 Jun;50(5):1566-1574. PubMed PMID: 29880387.
  • Pradhan-Sundd T, Vats R, Russell JM, Singh S, Michael AA, Molina L, Kakar S, Cornuet P, Poddar M, Watkins SC, Nejak-Bowen KN, Monga SP and Sundd P. Dysregulated bile transporters and impaired tight junctions during chronic liver injury in mice. Gastroenterology. 2018 Oct;155(4):1218-1232.e24. PubMed PMID: 29964040; PubMed Central PMCID: PMC6174089.
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  • Pulikkan JA†, Tenen DG†, Behre G†. C/EBPα deregulation as a paradigm for leukemogenesis. Leukemia. 2017 Nov;31(11):2279-2285. (†Corresponding author).
  • Fu G, Yu M, Chen Y, Zheng Y, Zhu W, Newman DK, Wang D, Wen R. Phospholipase Cγ1 is required for pre-TCR signal transduction and pre-T cell development. Eur J Immunol. 2017;47:74-83. PMID: 27759161; PMCID: PMC5559087.
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  • Sundd P, Ley K. Quantitative dynamic footprinting microscopy. Immunol Cell Biol. 2013;91(4):311-320. PMID: 23478358.

  • Muia J, Casari C. Reflections on scientific collaboration between basic researchers and clinicians. J Thromb Haemost. 2016;14:1905-1907.
  • Li R, Hoffmeister KM, Falet H. Glycans and the platelet life cycle. Platelets. 2016 Sep;27(6):505-11. doi: 10.3109/09537104.2016.1171304. Epub 2016 May 2. Review. PubMed PMID: 27135356; PubMed Central PMCID: PMC5102065.
  • Shi Q, Haribhai D, Luo X, Montgomery RR. Platelet-derived factor VIII is therapeutic in hemophilia A with high-titer inhibitory antibodies. J Clin Invest. 2016;126: 130. (Commentary)
  • Wang Z, Kaur G, Eslin D, Shi Q, Montgomery RR. Can Platelets Be Used to Store and Deliver Therapeutic Proteins? Mol Ther. 2016 Dec;24(12):2066-2077. doi: 10.1038/mt.2016.211. Epub 2016 Oct 26. Review. PubMed PMID: 27792520; PubMed Central PMCID: PMC5147985.
  • Shi Q. Gene therapy for hemophilia A using platelet derived FVIII. Hematol Oncol Clin North Am. 2016 Apr;30(2):437-452. doi: 10.1016/j.hoc.2015.11.006. Review. PubMed PMID: 27026545; PubMed Central PMCID: PMC4892985.
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  • Shi Q, Yu H, Ma X, Falet H, Griffiths H, Montgomery RR. Clinical translation of genetically engineered platelets for hemophilia. Blood. 2016 Dec 1;128(22):781. (Commentary)
  • Shi Q. Platelet-derived FVIII for gene therapy of hemophilia A. Gene Therapy. 2016;23: 643-645. (Commentary)
  • Marklin GF, Wilcox DA. Circulating factor VIII levels after platelet gene therapy. Blood. 2016 May 12;127(19):2384. doi: 10.1182/blood-2016-03-704882. PubMed PMID: 27165389; PubMed Central PMCID: PMC4889903.
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  • Jianghai Zhu, Jieqing Zhu, Daniel W. Bougie, Richard H. Aster, and Timothy A. Springer. Structural basis for quinine-dependent antibody binding to platelet integrin. Blood. 2015;126(18):2138-2145.
  • Jiafu Liu, Zhengli Wang, Aye Myat Myat Thinn, Yan-Qing Ma, and Jieqing Zhu. The dual structural roles of the membrane distal region of α integrin cytoplasmic tail during integrin inside-out activation. J Cell Sci. 2015;128(9):1718-1731.
  • Baumgartner KC, Kuether EL, Zhang G, Weiler H, Shi Q, and Montgomery RR. Native whole blood thrombin generation assay evaluates therapeutic efficacy of plasma and platelet-derived FVIII. J Thromb Haemost. 2015;13(12):2210-2219.
  • Shi Q, Schroeder JA, Kuether EL, and Montgomery RR. The important role of von Willebrand factor in platelet-derived factor VIII gene therapy of murine hemophilia A in the presence of inhibitory antibodies. J Thromb Haemost. 2015;13(7):1301-1309.
  • Schroeder JA, Chen Y, Fang J, Wilcox DA, and Shi Q. In vivo enrichment of manipulated platelets corrects the murine hemophilic phenotype and induces immune tolerance even using a low multiplicity of infection. J Thromb Haemost. 2015;13(8):1283-1293.
  • Chen Y, Schroeder JA, Chen J, Luo X, Baumgartner KC, Montgomery RR, Hu J, and Shi Q. The immunogenicity of platelets containing FVIII in murine hemophilia A with or without pre-existing anti-FVIII immunity. Blood. 2015;127(10):1346-1354.
  • Garcia J, Flood VH, Haberichter SL, Fahs SA, Mattson JG, Geurts AM, Zogg M, Weiler H, Shi Q, and Montgomery RR. A rat model of severe VWD by elimination of the VWF gene using CRISPR/Cas9. Res Pract Thromb Haemost. 2015.

  • Kanaji S, Fahs SA, Ware J, Montgomery RR, and Shi Q. Non-myeloablative conditioning with busulfan prior to hematopoietic stem cell transplantation leads to phenotypic correction of murine Bernard-Soulier Syndrome. J Thromb Haemost. 2014;12(10):1726-1732.
  • Mannucci PM, Shi Q, Bonanad S, and Klamroth R. Novel investigations on the protective role of the FVIII/VWF complex in inhibitor development. Haemophilia. 2014;20 Suppl 6:2-16.
  • Schroeder JA, Chen Y, Fang J, Wilcox DA, and Shi Q. In vivo enrichment of manipulated platelets corrects the murine hemophilic phenotype and induces immune tolerance even using a low multiplicity of infection. J Thromb Haemost. 2014;12(8):1283-1293.
  • Fahs SA, Hille MT, Shi Q, Weiler H, and Montgomery RR. Conditional knockout mouse model reveals endothelial cells as the predominant and possibly exclusive source of plasma factor VIII. Blood. 2014;123(24):3706-3713.
  • Shi Q, Kuether EL, Chen Y, Schroeder JA, Fahs SA, and Montgomery RR. Platelet gene therapy corrects the hemophilic phenotype in immunocompromized hemophilia A mice transplanted with genetically manipulated human cord blood stem cells. Blood. 2014;123(3):395-403.
  • Chen Y, Schroeder JA, Kuether EL, Zhang G, and Shi Q. Lentivirus-mediated platelet gene therapy corrects bleeding diathesis and induces humoral immune tolerance in hemophilia B mice. Mol Ther. 2014;22(1):169-177.
  • Du LM, Nurden P, Nurden AT, Nichols TC, Bellinger DA, Jensen ES, Haberichter SL, Merricks E, Paymer RA, Fang J, Koukouritaki SB, Jacobi PM, Hawkins TB, Cornetta K, Shi Q, and Wilcox DA. Platelet α-granules containing human factor VIII induce hemostasis for canine hemophilia A. Nat Commun. 2014;4:2773.
  • Shi Q, Kuether EL, Schroeder JA, Perry CL, Fahs SA, Gil JC, and Montgomery RR. FVIII inhibitors: VWF makes a difference in vitro and in vivo. J Thromb Haemost. 2014;10(11):2328-2337.

  • Du LM, Nurden P, Nurden AT, Nichols TC, Bellinger DA, Jensen ES, Haberichter SL, Merricks E, Paymer RA, Fang J, Koukouritaki SB, Jacobi PM, Hawkins TB, Cornetta K, Shi Q, and Wilcox DA. Platelet α-granules containing human factor VIII induce hemostasis for canine hemophilia A. Nat Commun. 2013;4:2773.
  • Chuanmei Zhang, Jiafu Liu, Xiuli Jiang, Nada Haydar, Can Zhang, Hu Shan, and Jieqing Zhu. Modulation of integrin activation and signaling by α1/α1′-helix unbending at the junction. J Cell Sci. 2013;126(24):5735-5747.
  • Jieqing Zhu, Jianghai Zhu, and Timothy A. Springer. Complete integrin headpiece opening in eight steps. J Cell Biol. 2013;201(7):1053-1068.
  • Fatkhullina AR, Peshkova IO, Dzutsev A, Aghayev T, McCulloch JA, Thovarai V, Badger JH, Vats R, Sundd P, Tang HY, Kossenkov AV, Hazen SL, Trinchieri G, Grivennikov SI, and Koltsova EK. An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis. Immunity. 2013;49(5):943-957.e9.
  • Huang W, Li R, Zhang J, Chen Y, Ramakrishnan DP, Silverstein RL. A CD36 transmembrane domain peptide interrupts CD36 interactions with membrane partners on macrophages and inhibits atherogenic functions. Transl Res. 2013.
  • Yarovoi H, Kufrin D, Eslin DE, Thornton MA, Haberichter SL, Shi Q, Zhu H, Camire R, Farharzadeh SS, Kowalska MA, Wilcox DA, Montgomery RR, and Poncz M. Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. Blood. 2013;102(12):4006-4013.

  • Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M, Poliakov E, Sun M, Finton PJ, Curtis BR, Chen J, Zhang R, Silverstein RL, and Hazen SL. Platelet CD36 links hyperlipidemia, oxidant stress and a pro-thrombotic phenotype. Nat Med. 2012;13(9):1086-1095.
  • Kanaji S, Kuether EL, Schroeder JA, Fahs SA, Ware J, Montgomery RR, Shi Q. Lentivirus-mediated gene therapy of Bernard-Soulier Syndrome in a GPIbα deficient mouse model. Mol Ther. 2012;20(3):625-632.
  • Shi Q, Kuether EL, Schroeder JA, Perry CL, Fahs SA, Gil JC, Montgomery RR. FVIII inhibitors: VWF makes a difference in vitro and in vivo. J Thromb Haemost. 2012;10(11):2328-2337.
  • Montgomery RR, Shi Q. Platelet and endothelial expression of clotting factors for the treatment of hemophilia. Thromb Res. 2012;129(Suppl 2):S46-S48.
  • Zhu W, Zheng Y, Yu M, Wu Y, Wei J, Zhou L, Fu G, Schneider N, Jones C, Irani M, Padmanabhan A, Aster R, Wang D, Wen R. Cloned antibodies from patients with heparin-induced thrombocytopenia provide new clues to HIT pathogenesis. Blood. 2012;141:1060-1069.
  • Yan-Feng Zhou, Eng ET, Jieqing Zhu, Lu C, Walz T, Springer TA. Sequence and structure relationships within von Willebrand factor. Blood. 2012;120(2):449-458.
  • Bougie DW, Rasmussen MH, Jieqing Zhu, Aster RH. Antibodies causing thrombocytopenia in patients treated with RGD-mimetic platelet inhibitors recognize ligand-specific conformers of αIIbβ3 integrin. Blood. 2012;119(26):6317-6325.
  • Jieqing Zhu, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Thomas CJ, Filizola M, Springer TA, Coller BS. Structure-guided design of a high affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS. Sci Transl Med. 2012;4(125):125ra32.
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  • Ren B, Hale J, Srikanthan S, Silverstein RL. Lysophosphatidic Acid Suppresses Endothelial Cell CD36 Expression and Promotes Angiogenesis via a PKD-1 Dependent Signaling Pathway. Blood. 2011;117(22):6036-6045.
  • Sundd P, Gutierrez E, Petrich BG, Ginsberg MH, Groisman A, Ley K. Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting. Microcirculation. 2011;18(5):361-372.
  • Stadtmann A, Germena G, Block H, Boras M, Rossaint J, Sundd P, Lefort C, Fisher CI, Buscher K, Gelschefarth B, Urzainqui A, Gerke V, Ley K, Zarbock A. The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow. J Exp Med. 2011;210(11):2171-2180.
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  • Shi Q, Kuether EL, Schroeder JA, Fahs SA, Montgomery RR. Intravascular recovery of VWF and FVIII following intraperitoneal injection and differences from intravenous and subcutaneous injection in mice. Haemophilia. 2011;18(4):639-646.
  • Kanaji S, Kuether EL, Schroeder JA, Fahs SA, Ware J, Montgomery RR, Shi Q. Lentivirus-mediated gene therapy of Bernard-Soulier Syndrome in a GPIbα deficient mouse model. Mol Ther. 2011;20(3):625-632.
  • Pulikkan JA, Madera D, Xue L, Bradley P, Landrette SF, Kuo YH, Abbas S, Zhu LJ, Valk P, Castilla LH. Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling. Blood. 2011;120(4):868-879.
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