Single Gene Sequence Analysis – CPT Codes
Confidence begins with clarity.
Versiti has variant classification policies that are founded in established practice and are guided with unparalleled experience in hematology.
Our genetic tests are specifically designed and optimized for the detection of germline variants known to cause or contribute to numerous common and rare hematological disorders.
We adhere to the 5-tier classification system outlined in the American College of Medical Genetics (ACMG) Standards and Guidelines, which are nationally recognized recommendations for clinical variant interpretation among genetic testing laboratories:
- Pathogenic: Conclusive evidence demonstrates that the variant directly causes or contributes to disease
- Likely Pathogenic: Strong evidence supports that the variant causes or contributes to disease
- Uncertain Significance: Current evidence on the identified variant is insufficient or inconclusive
- Likely Benign: Strong evidence supports that the variant does not cause or contribute to disease
- Benign: Conclusive evidence that the variant does not cause or contribute to disease
Parental/Patient/Pediatric: 3-5 mL whole blood (EDTA tube, lavender top), 2-5 mL bone marrow (EDTA tube, lavender top), 3-4 Buccal swabs or ≥1ug of DNA at ≥50ng/uL of high-quality DNA.
Fetal: Direct: 7-15 mL amniotic fluid, 5-10 mg chorionic villi; backup culture of amniocytes or chorionic villi is highly recommended. Cultured: two T25 flasks cultured amniocytes or chorionic villi (2x10^6 minimum). Maternal blood sample of 3-5 mL whole blood (EDTA tube, lavender top) is requested for all prenatal samples for maternal cell contamination studies.
Ship on an ice pack or at room temperature. Protect from freezing. Place the specimen and the requisition into plastic bags and seal. Insert into a Styrofoam container, seal and place into a sturdy cardboard box, and tape securely. Ship the package in compliance with your overnight carrier guidelines.
Label with the following address:
Client Services/Diagnostic Laboratory
BloodCenter of Wisconsin
638 N. 18th St.
Milwaukee, WI 53233