Versiti - Immunohematology Reference Laboratory

Immunohematology Reference Laboratories

Versiti’s Immunohematology Reference Labs support all types of transfusion medicine cases.

Experts in resolving complex immunohematology cases

Versiti’s Immunohematology Reference Laboratories (IRL) are highly specialized areas that focus on the identification and resolution of red cell transfusion-related problems. We have become known as the reference lab of reference labs, as our team of experts includes renowned physicians and the largest collection of SBB-certified technologists in America. Our IRLs are accredited by the American Association of Blood Banks (AABB) and maintain satisfactory standing with all inspection agencies.


Our reference labs offer:

  • 24/7 coverage, including weekends and holidays 
  • Easily accessible and courteous staff 
  • Serologic investigation and consultation 
  • Procurement of antigen-negative donor units 
  • Response to requests for rare donor units from the American Rare Donor Program (ARDP)

Versiti ensures the provision of antigen-negative and rare units. The Versiti Immunohematology Reference Laboratory is available 24/7 to provide antigen-typed red cells. From our headquarters to our depots, we carry an abundant supply of readily available antigen-negative units. We leverage information on more than 250,000 genotyped donors, the largest known pool of genotyped donors in the United States. This resource allows us to support the vast majority of antigen-negative requests, including rare antigens. In the uncommon event that we cannot fulfill a rare unit request, we seek assistance from the American Rare Donor Program (ARDP).

Medical consultative services are provided by our team of more than 20 highly qualified transfusion medicine specialists, 24 hours a day, 7 days a week. Their expertise and this service transcend all aspects of transfusion medicine, including routine transfusion problems, platelet disorders, bleeding and thrombolytic disorders, transplantation, and therapeutic apheresis. This service is triggered by a 24/7 on-call physician, a rotational responsibility shared within this physician team.

  • Aberrant or discrepant result investigations
  • Antibodies to high- and low-incidence antigens
  • Auto-antibodies
  • Drug-dependent antibodies
  • Hemolytic disease of the newborn investigations
  • Reagent-dependent reactivity
  • Single to complex multiple antibodies
  • Transfusion reaction investigations

  • ABO discrepancies
  • Discrepant red cell antigen typing
  • Donor/patient red cell phenotype and genotype (serologic and molecular testing available)
  • Polyagglutination investigation
  • Prenatal evaluations (ABO/Rh, ABID, titer)
  • Weak antigen expression investigations

Diagnostic samples and/or infectious substances must be packaged in compliance with Department of Transportation (DOT), International Air Transport Association (IATA), and the specific requirements of the overnight carrier used.
Diagnostic Laboratories
Diagnostic laboratory services including HLA testing, donor testing, immunohematology reference lab testing, hematology testing and more.
Our Experts
Research investigators, postdoctoral fellows and laboratory staff at Versiti Blood Research Institute and Diagnostic Laboratories.
Access requisitions for Versiti Diagnostic Laboratories.
Specialty Products & Services
Versiti offers a number of specialty products and services, including matched platelets, autologous and directed donations, and therapeutic phlebotomy.