Chimerism Testing For Engraftment

Rapid and highly sensitive chimerism lab tests for post-transplant monitoring.

What is Chimerism?

 

Chimerism occurs when a person’s body contains two different sets of DNA. Versiti Diagnostic Labs offers sophisticated chimerism testing for post-transplant patients, including those who received solid organ transplantation, bone marrow transplantation and cellular therapy treatments. 

Versiti Diagnostic Laboratories’ expertise includes:

  • More than 30 years of chimerism test experience in post-transplant monitoring and cell therapy
  • Four-day testing turnaround time with low limit of detection
  • Chimerism testing on cell enrichment types CD3, CD19, CD33, CD56

We support our transplant partners by helping to monitor the relative amounts of recipient and donor cells after transplantation. Important clinical events in allogenic bone marrow transplantation, such as engraftment, relapse and the effects of post-transplant therapies, can be monitored on a molecular level by using inherent genetic differences between recipients and donors.

 Versiti Diagnostic Labs’ genetic chimerism testing has proven reliability, demonstrated by consistent, accurate, precise performance in proficiency programs.

Enriched Cell Populations

Enriched cell populations can also be used to monitor patients following hematopoietic stem cell transplant for more precise detection of changes in transplant dynamics. Testing for the following cell subtypes is available:

Cell MarkerCell Subset
CD19B cells
CD56Natural Killer (NK) cells

Indications For Testing

  • Monitor hematopoietic reconstruction following allogenic bone marrow transplantation
  • Monitor effects of post-transplant therapies
  • Monitor minimal residual disease or relapse
 
Diagnostic Laboratories
Diagnostic laboratory services including HLA testing, donor testing, immunohematology reference lab testing, hematology testing and more.
 
Our Experts
Research investigators, postdoctoral fellows and laboratory staff at Versiti Blood Research Institute and Diagnostic Laboratories.
 
Human Leukocyte Antigen (HLA) Typing
Versiti Diagnostic Labs’ Histocompatibility Lab provides human leukocyte antigen (HLA) typing for solid organ and stem cell transplant patients.
 
Molecular Oncology Testing
Molecular oncology lab tests to help diagnose blood cancers like acute myeloid leukemia, chronic myelogenous leukemia and more.