HPA Gene Database

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HPA Gene Database

The following table details genetic information about HPA Antigens. The following conventions are used in the table:

Nucleotide numbers are given in relation to the reference sequence in the NCBI database, as indicated in the RefSeq column, and we have used the numbering convention as recommended by Antonarakis (Hum Mutat 1998;11:1-3) whereby the A of the start codon is +1.
Nucleotide and protein substitutions are shown as changes from the higher frequency (a) allele to the less common (b) allele. In certain cases, e.g. HPA-5, the reference sequence encodes the less common form.

Search the HPA Gene Database

Use the database below to search for any of the current 35 recognized human platelet antigens. Search by number, 1-35 to jump to a specific antigen.

HPA	HGNC Gene	Chromosome	Entrez Gene	Ref-Seq	Uni-Prot	dbSNP	Nucleotide Change	Precursor Protein	Mature Protein	Reference
HPA-1b	ITGB3	17	3690	NM 000212	ITB3 Human	rs5918	176T>C	L59P	L33P	Newman et al, J Clin Invest (1989)
HPA-2b	GP1BA	17	2811	NM_000173	GPBA_Human	rs6065	482C>T	T161M	T145M	Kuijpers et al, J Clin Invest (1992)
HPA-3b	ITGA2B	17	3674	NM_000419	ITAB_Human	rs5911	2621T>G	I874S	I843S	Lyman et al, Blood (1990)
HPA-4b	ITGB3	17	3690	NM_000212	ITB3_Human	rs5917	506G>A	R169Q	R143Q	Wang et al, J Clin Invest (1992) Wang et al, Proceedings of the Japan Academy (1991)
HPA-4	ITGB3	17	3690	NM_000212	ITB3_Human	rs5917	506G>A	R169Q	R143Q	Wang et al, Proceedings of the Japan Academy 67:102-6 (1991)
HPA-5b	ITGA2	5	3673	NM_002203	ITA2_Human	rs1801106	1600G>A	E534K	E505K	Santoso et al, J Clin Invest(1993) Kalb et al, Thromb Haemost (1994) Simsek et al, Br J Haematol (1994)
HPA-5	ITGA2	5	3673	NM_002203	ITA2_Human	rs1801106	1600G>A	E534K	E505K	Kalb et al, Thromb Haemost 71:651-4 (1994)<
HPA-5	ITGA2	5	3673	NM_002203	ITA2_Human	rs1801106	1600G>A	E534K	E505K	Simsek et al, Br J Haematol 86:671-4 (1994)
HPA-6b	ITGB3	17	3690	NM_000212	ITB3_Human	rs13306487	1544G>A	R515Q	R489Q	Wang et al, Blood (1993)
HPA-7b	ITGB3	17	3690	NM_000212	ITB3_Human	rs121918448	1297C>G	P433A	P407A	Kuijpers et al, Blood (1993)
HPA-8b	ITGB3	17	3690	NM_000212	ITB3_Human	rs151219882	1984C>T	R662C	R636C	Santoso et al, J Biol Chem (1994)
HPA-9b	ITGA2B	17	3674	NM_000419	ITAB_Human	rs74988902	2602G>A	V868M	V837M	Noris et al, Blood (1995)
HPA-10b	ITGB3	17	3690	NM_000212	ITB3_Human	rs200358667	263G>A	R88Q	R62Q	Peyruchaud et al, Blood (1997)
HPA-11b	ITGB3	17	3690	NM_000212	ITB3_Human	rs377302275	1976G>A	R659H	R633H	Simsek et al, Blood (1997)
HPA-12b	GP1BB	22	2812	NM_000407	GPBB_Human	rs375285857	119G>A	G40E	G15E	Sachs et al, Blood (2000)
HPA-13b	ITGA2	5	3673	NM_002203	ITA2_Human	rs79932422	2483C>T	T828M	T799M	Santoso et al, Blood (1999)
HPA-14b	ITGB3	17	3690	NM_000212	ITB3_Human		1909_1911delAAG	K637del	K611del	Santoso et al, Blood (2002)
HPA-15b	CD109	8	135228	NM_133493	Q8TDJ3	rs10455097	2108C>A	S703Y	S682Y	Schuh et al, Blood (2002)
HPA-16b	ITGB3	17	3690	NM_000212	ITB3_Human	rs74708909	497C>T	T166I	T140I	Jallu et al, Blood (2002)
HPA-17b	ITGB3	17	3690	NM_000212	ITB3_Human	rs770992614	662C>T	T221M	T195M	Stafford et al, Transfusion (2008)
HPA-18b	ITGA2	5	3673	NM_002203	ITA2_Human	rs267606593	2235G>T	Q745H	Q716H	Bertrand et al, Transfusion (2009)
HPA-19b	ITGB3	17	3690	NM_000212	ITB3_Human	rs80115510	487A>C	K163Q	K137Q	Peterson et al, Transfusion (2009)
HPA-20b	ITGA2B	17	3674	NM_000419	ITAB_Human	rs78299130	1949C>T	T650M	T619M	Peterson et al, Transfusion (2010)
HPA-21b	ITGB3	17	3690	NM_000212	ITB3_Human	rs70940817	1960G>A	E654K	E628K	Peterson et al, Transfusion (2010)
HPA-22b	ITGA2B	17	3674	NM_000419	ITAB_Human	rs142811900	584A>C	K195T	K164T	Peterson et al, Transfusion (2012)
HPA-23b	ITGB3	17	3690	NM_000212	ITB3_Human	rs139166528	1942C>T	R648W	R622W	Peterson et al, Transfusion (2012)
HPA-24b	ITGA2B	17	3674	NM_000419	ITAB_Human	rs281864910	1508G>A	S503N	S472N	Jallu et al, Transfusion (2011)
HPA-25b	ITGA2	5	3673	NM_002203	ITA2_Human	rs771035051	3347C>T	T1116M	T1087M	Kroll et al, Transfusion (2011)
HPA-26b	ITGB3	17	3690	NM_000212	ITB3_Human	rs1156382155	1818G>T	K606N	K580N	Sachs et al, Thromb Haemost (2012)
HPA-27b	ITGA2B	17	3674	NM_000419	ITAB_Human	rs149468422	2614C>A	L872M	L841M	Jallu et al, Transfusion (2013)
HPA-28b	ITGA2B	17	3674	NM_000419	ITAB_Human	rs368953599	2311G>T	V771L	V740L	Poles et al, Transfusion (2013)
HPA-29b	ITGB3	17	3690	NM_000212	ITB3_Human	rs544276300	98C>T	T33M	T7M	Sullivan et al, Transfusion (2015)
HPA-30b	ITGA2B	17	3674	NM_000419	ITAB_Human	rs377753373	2511G>C	Q837H	Q806H	Wihadmadyatami et al, Transfusion (2015)
HPA-31b	GP9	3	2815	NM_000174	GPIX_Human	rs202229101	368C>T	P123L	P107L	Jallu et al, J Thromb Haemost (2017)
HPI-32b	ITGB3	17	3690	NM_000212	ITB3_Human	rs879083862	521A>G	D174S	D148S	Sullivan et al, Transfusion (2017)
HPA-33b	ITGB3	17	3690	NM_000212	ITB3_Human	rs1555572829	1373A>G	D458G	D432G	Poles et al, Transfusion (2019)
HPA-34b	ITGB3	17	3690	NM_000212	ITB3_Human	rs777748046	349C>T	R117W	R91W	Bertrand et al, Transfusion (2019)
HPA-35b	ITGB3	17	3690	NM_000212	ITB3_Human	rs779974422	1514A>G	R505H	R479H	Bertrand et al, Transfusion (2019)

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Please use the following format to cite this website for publication purposes: Versiti (October, 2020). HPA Database. Retrieved from https://www.versiti.org/hpa-gene.